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Ligon Lab - Personalized Medicine and Brain Tumor Research

Ligon Lab
PERSONALIZED MEDICINE AND BRAIN TUMOR RESEARCH

Principal Investigator

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Keith L. Ligon, MD, PhD

Dana-Farber Cancer Institute
Department of Pathology
Jimmy Fund Bldg. JF215B
450 Brookline Avenue
Boston, MA 02115

Phone: 617-632-2357
Fax: 617-582-8761
Email: keith_ligon@dfci.harvard.edu

CV
Education and Training
1989                   B.A. Rice University (Biochemistry), Houston, TX
1996                   Ph.D. The University of Texas-M.D. Anderson Cancer Center/ The University of Texas- Houston Graduate School of Biomedical Sciences                                            M.D./Ph.D. Program, (Biochemistry and Molecular Biology), Houston, TX
 1997                  M.D. The University of Texas-Houston Medical School M.D./ Ph.D. Program, Houston, TX
 1997 - 1999      Resident in Anatomic Pathology, Brigham and Women’s Hospital, Boston, MA.
 1999 - 2001      Clinical Fellow in Neuropathology, Brigham and Women’s Hospital/ Children’s Hospital Combined Training Program, Boston, MA
 2001 - 2004      Research Fellow, Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA (Mentor: Dr. David H. Rowitch)
   
Licensure and Certification
1998                    American Board of Medical Examiners
2000                    Commonwealth of Massachusetts Board of Registration in Medicine
2001                    American Board of Pathology (Combined Anatomic Pathology/ Neuropathology)
   
Awards and Honors
1985 - 1989        National Merit Scholar, Rice University
1986                    Sir Alexander Fleming Scholar, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma
1989 - 1992        Academic Scholar, University of Texas-Houston Medical School
2006                    Matthew T. Moore Distinguished Lecture in Neuropathology, International Congress of Neuropathology, San Francisco, CA
2006                    Research Award, Brigham Research Institute, Cancer Center Retreat
2007                    Memorial Peter A. Steck Award in Brain Tumor Research
2007                    Barr Award
2008                    Dunkin Donuts Rising Star Award
   
Research Interests
Abnormalities of neural stem/progenitor cell proliferation and differentiation are responsible for the majority of human brain tumors and a broad range of neurologic diseases. However, the specific transcriptional networks controlling stem/progenitor cell growth in normal cells and neurologic cancer are poorly understood. To address this area, my lab research has been directed towards identifying the transcription factor networks that control these processes, and elucidating their function using techniques in mouse genetics, translational human research, and molecular neuropathology.
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